Christopher er femten år og lider av en mild form for autisme. En dag finner han hunden til Mrs Shears stukket i hjel med en høygaffel og bestemmer seg for, som selveste Sherlock Holmes, å løse myster The Curious Incident of the Dog in the Night-Time is a murder mystery novel like no other. The detective, and narrator, is Christopher Boone. Christopher is fifteen and has Asperger's, a form of autism. He knows a very great deal about maths and very little about human beings. He loves lists, patterns and the truth. He hates the colours yellow and brown and being touched. He has never gone further than the end of the road on his own, but when he finds a neighbour's dog murdered he sets out on a terrifying journey which will turn his whole world upside down.