The 5-volume set LNCS constitutes the proceedings of the International Conference on Extended Reality, XR Salento 2026, held in Otranto, Italy, during June 2026. The 154 full papers and 67 short papers presented in these volumes were carefully reviewed and selected from 262 submissions. The papers are organized in the following topical sections:Part I: Virtual Reality; Augmented and Mixed RealityPart II: Extended Reality; Extended Reality in Education; Extended Reality in Medicine. Part III: XR for Art, Design, and Entertainment; Extended Reality for Archaeological Heritage: Integration, Validation, Reconstruction and Dissemination; AI-driven, Interactive, virtual and conversational agents in Cultural Heritage; Virtual Restoration and Digital Twins for Cultural Heritage; Artificial Intelligence and Digital Twins. Part IV: Digital Transformation and Advanced Technologies in Healthcare: From Complex Systems Modeling to XR-Driven Innovation; Extended Reality, Artificial Intelligence, and Biosignals in Biomedical Applications; Extended Reality in Rehabilitation. Part V: Digital Transformation and Advanced Technologies in Industry: From Complex Systems Modeling to XR-Driven Innovation; New Trends in Learning in the Virtual World; New Trends in Training in the Virtual World.
