Inducing Targeted Protein Degradation - From Chemical Biology to Drug Discovery and Clinical Applications

Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation

Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space.

In Inducing Targeted Protein Degradation, readers will find the most recent information on:

• Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery
• A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications
• Drug dev