This book, now in an extensively revised second edition, is a complete reference for all clinicians who are interested in incorporating into their daily practice the techniques available to reduce the duration of orthodontic treatment and overcome other treatment limitations. The opening chapters describe the new concepts in biology of tooth movement, the biological principles of current accelerated techniques at the molecular and cellular levels, and introduce guidelines on how to select the best acceleration approach based on each patient’s needs. New chapters have been added describing how age and individual variability can affect the rate of tooth movement. Clinicians are then introduced to micro-osteoperforations (MOPs) as an efficient approach to increase the rate of tooth movement. They will be guided step by step through the application of MOPs, case selection, and treatment planning, and learn how MOPs can be incorporated into daily mechanotherapy for the treatment of different malocclusions. The book is written in simple and clear language with many illustrations and clinical examples to facilitate understanding of concepts and procedures. In addition, it is a rich source for academicians and researchers interested in a comprehensive and updated review of theories of tooth movement and accelerated orthodontic techniques.