The conceptual basis to summarize and predict the in vivo behavior and the related mathematical descriptions and models of creatine and creatinine are currently based on the principles and methodologies of pharmacokinetics and pharmacodynamics. Most in vivo kinetic analyses and models of creatine and creatinine are assumed to be linear. The presence of nonlinear in vivo kinetics for creatine is assessed by the author due to the affinity and preferential uptake of the molecule in the muscle. This book is an inquiry into the application of these principles and methodologies for the endogenous compounds creatine and creatinine, and provides new pathways for studies and bench research. Key FeaturesDiscusses the term 'in vivo kinetics' and related rates for defining the production, distribution, metabolism and excretion (PDME) of creatine and creatinine. Evaluates the current kinetic models of creatine and creatinine, and other applied modeling approaches. Uses an integrated interdisciplinary approach in addressing the kinetics and dynamics of creatine and creatinine. Establishes new pathways in creatine and creatinine studies and bench research.
