How can we design our lives to be sustainable amidst an uncertain future for our planet? How do we know what to trust in an online world rife with misinformation? How can we confront our mental health crises? How can we overcome polarization on issues of critical importance to our shared existence?How can we work together with those who see the world differently to us?As this open access book demonstrates, confronting these questions requires us to consider what the -future of knowledge- might be, including the distinctive roles that disciplines across the sciences, arts and humanities might play. Epistemic insight is the -knowledge about knowledge- needed to navigate the similarities and differences between disciplines and how they approach these questions differently. However, many education systems operate with a compartmentalized structure that limits the development of epistemic insight and thus our ability to provide students with the -knowledge