The two-volume set LNBIP 592 + 593 constitutes the refereed proceedings of the 25th Wuhan International Conference on E-Business, WHICEB 2026, which was held in Wuhan, China, during May 2026. This year's conference theme was "Navigating the Future: Digital Platforms, Intelligent Technologies, and Sustainable Ecosystems for Global Enterprise". The 116 full papers included in the proceedings were carefully reviewed and selected from 434 submissions. They have been organized in topical sections as follows: Part I: Conference Theme Track.- AIGC Development & Governance.- Artificial Intelligence and New Ways of Working.- Data Science and Analytics.- Digital Enablement and Governance.- Digital Tourism.- Digital Strategy and Social Impact in Business Ecosystem.- E-commerce Platform and Operations.- Engaging Technologies and Immersive Design.- Part II: GenAI and User Behavior.- Human-AI Interaction.- Intelligent Marketing and Consumer Insights.- IS in Healthcare Service.- Next-Gen Technologies in Social Commerce.- Social Computing on Digital Platforms.- Transformative Digital Service and Impact.- General IS and Digital Business Topics.
