Chasing Pain: The Search for a Neurobiological Mechanism

Chasing Pain discusses the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. The limitation of current pain models is exemplified by considering several important, therapeutically challenging clinical conditions that remain very poorly understood. Realistic models of pain neurobiology must consider that the normally tight link between pain and tissue damage is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes.